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Frédéric Calon

Formation
B.Sc (biochimie)
B.Pharm (Pharmacie)
Ph.D.

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Principal area
Neuroscience
Address
2705, boulevard Laurier, T-2-50
Québec (Quebec)
CANADA G1V 4G2
Phone
+1 418-525-4444, extension 48697
Fax
+1 418-654-2298
Email
Frederic.Calon@crchul.ulaval.ca

Dr Frederic Calon is biochemist-pharmacist dedicated to the development of new treatment for neurodegenerative diseases, which affect more that 500,000 Canadians. Dr Calon and his collaborators have contributed to the discovery of a neuroprotective effect of omega-3 fatty acids in animal models of Alzheimer's and Parkinson’s disease. He has published over 68 papers, including in highly-cited journals in the field of neuroscience. Dr Calon was recruited at Université Laval in July 2003 where he gathered significant support from the Canadian Institutes of Health Research (CIHR), the Alzheimer Society Canada (ASC), the Parkinson Society Canada, the Canadian Foundation for Innovation and other organisms. Dr Calon’s research team currently comprises 1 postdoctoral fellow, 7 graduate students and 2 research professionals. The ultimate goal of his research is to accelerate the transfer of knowledge from basic neuroscience to clinical applications for brain diseases.

 

Research project(s) recognized by Université Laval (in French)

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Recent publications (see all publication from this researcher)

Bousquet M, St-Amour I, Vandal M, Julien P, Cicchetti F, Calon F. High-fat diet exacerbates MPTP-induced dopaminergic degeneration in mice. Neurobiology of disease,  2012. 45: 529-38
Lebbadi M, Julien C, Phivilay A, Tremblay C, Emond V, Kang JX, Calon F. Endogenous conversion of omega-6 into omega-3 Fatty acids improves neuropathology in an animal model of Alzheimer's disease. Journal of Alzheimer's disease : JAD,  2011. 27: 853-69
Drouin-Ouellet J, Gibrat C, Bousquet M, Calon F, Kriz J, Cicchetti F. The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration. Journal of neuroinflammation,  2011. 8: 137
Delay C, Calon F, Mathews P, Hebert SS. Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function. Molecular neurodegeneration,  2011. 6: 70
Paris-Robidas S, Brochu E, Sintes M, Emond V, Bousquet M, Vandal M, Pilote M, Tremblay C, Di Paolo T, Rajput AH, Rajput A, Calon F. Defective dentate nucleus GABA receptors in essential tremor. Brain : a journal of neurology,  2011. Epub
Tremblay C, St-Amour I, Schneider J, Bennett DA, Calon F. Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease. Journal of neuropathology and experimental neurology,  2011. 70: 788-98
Bousquet M, Gue K, Emond V, Julien P, Kang JX, Cicchetti F, Calon F. Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease. Journal of lipid research,  2011. 52: 263-71
Zhao Y, Calon F, Julien C, Winkler JW, Petasis NA, Lukiw WJ, Bazan NG. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARgamma-mediated mechanisms in Alzheimer's disease models. PLoS ONE,  2011. 6: e15816
Arsenault D, Julien C, Tremblay C, Calon F. DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice. PLoS ONE,  2011. 6: e17397
Bousquet M, Calon F, Cicchetti F. Impact of omega-3 fatty acids in Parkinson's disease. Ageing research reviews,  2011. 10: 453-63
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