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Neuroscience

Director
Guy Drolet
Address
2705, boulevard Laurier, RC-9800
Québec (Québec)
CANADA G1V 4G2
Phone
+1 418-654-2152
Fax
+1 418-654-2753
Email
neurosciences@crchuq.ulaval.ca

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All active clinical studies

The neuroscience group is organized into multidisciplinary teams that study the biological mechanisms underpinning the normal and pathological functioning of the central and peripheral nervous system and the muscular system. Researchers in this field seek to advance our understanding of physiopathology and develop new treatments for deficiencies and disabilities caused by lesions or neurological, psychiatric, and neuromuscular diseases. Research themes concern neurodegenerative, neuromuscular, and neurogenetic diseases, cerebral and spinal lesions and trauma, the regeneration and reorganization of the nervous system, mental health, ophthalmology, the development of biotherapy and standardized clinical evaluation methods, and neuromodulation treatments. Researchers are very active in Université Laval’s Regroupement Neurosciences et Santé mentale (Neurosciences and Mental Health Group).

Active research projects (see all research project in this area)

Rôle du système immunitaire dans la réparation des dommages causés par l'ischémie-reperfusion
Benoît Lapointe
Rôle des microARNs dans la régulation de la pathologie de Tau
Sébastien Hébert
Rôle des microARNs dans le développement des neurones
Sébastien Hébert
Réponse immunitaire dans la maladie de Parkinson et d'Huntington
Denis Soulet
Aspects fondamentaux de la maladie d'Alzheimer
Georges Lévesque
FB-1812: Développement du procédé de manufacture
Pierre Savard
La protéine tau: régulation et dérégulation in vivo
Emmanuel Planel
La surconsommation en sel est-elle associée à un processus naturel de récompense lié au besoin et à la saveur du sel
Guy Drolet, Didier Mouginot
Fonctionnement du réseau de neurones du cerveau impliqué dans le contrôle de la consommation de sel
Didier Mouginot
Étude de la régulation d’expression des gènes des intégrines durant la cicatrisation cornéenne
Sylvain Guérin

Recent publications (see all publications in this area)

Khandjian EW, Tournier B, Séguin S, Tremblay S, De Koninck P, Davidovic L. RNA granules : functions within presynaptic terminals and postsynaptic spines (Chapter 2035) In: Squire LR, ed.  Encyclopedia of Neuroscience Boston, MA: Elsevier, 2009. p.389-95.
Julien C, Tremblay C, Emond V, Lebbadi M, Salem N Jr, Bennett DA, Calon F. Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease. Journal of neuropathology and experimental neurology,  2009. 68: 48-58
Danilenko KV, Plisov IL, Wirz-Justice A, Hebert M. Human retinal light sensitivity and melatonin rhythms following four days in near darkness. Chronobiology international,  2009. 26: 93-107
Poulin JF, Castonguay-Lebel Z, Laforest S, Drolet G. Enkephalin co-expression with classic neurotransmitters in the amygdaloid complex of the rat. The Journal of comparative neurology,  2008. 506: 943-59
Danilenko KV, Plisov IL, Hebert M, Krauchi K, Wirz-Justice A. Influence of timed nutrient diet on depression and light sensitivity in seasonal affective disorder. Chronobiology international,  2008. 25: 51-64
Iacoangeli A, Rozhdestvensky TS, Dolzhanskaya N, Tournier B, Schutt J, Brosius J, Denman RB, Khandjian EW, Kindler S, Tiedge H. Reply to Bagni: On BC1 RNA and the fragile X mental retardation protein. Proceedings of the National Academy of Sciences of the United States of America,  2008. 105: E29
Lukong KE, Chang KW, Khandjian EW, Richard S. RNA-binding proteins in human genetic disease. Trends in genetics : TIG,  2008. 24: 416-25
Schneider C, Nadeau L, Bard C, Lambert J, Majnemer A, Malouin F, Robaey P, St-Amand P, Tessier R. Visuo-motor coordination in 8-year-old children born pre-term before and after 28 weeks of gestation. Developmental neurorehabilitation,  2008. 11: 215-24
Méthot M, Demers E, Bussières S, Desbat B, Breton R, Salesse C. Phospholipid monolayer hydrolysis by cytosolic phospholipase A2 gamma and lecithin retinol acyl transferase Colloids and surfaces. A, Physicochemical and engineering aspects,  2008. 321: 147-150
Calon F, Cicchetti F. Can we prevent Parkinson's disease with n-3 polyunsatured fatty acids? Future lipidology,  2008. 3: 133-138
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