Endocrinology and genomics
- Director
- Jacques Simard
- Address
- 2705, boulevard Laurier, T-3-67
Québec (Québec)
CANADA G1V 4G2 - Phone
- +1 418-654-2296
- Fax
- +1 418-654-2298
No active offer
All active job offersNo active study
All active clinical studiesThe endocrinology and genomics group studies hormonal mechanisms and endocrine disorders associated with steroids and neuropeptides. As hormones modulate gene expression in target tissues, genomics was a natural addition over the years to the research program in this area. The group focuses particular attention on identifying and evaluating the contribution of genetic determinants to complex diseases. The main topics studied in this cutting-edge sector include biosynthesis, inactivation, description and control of hormone action, and genetic aspects of hormonal diseases. Researchers draw on an array of technologies including cellular and molecular biology, gene expression, genomics, proteomics, medicinal chemistry, protein crystallography, mass spectrometry, genetically-modified mice, and bioinformatics.
Researchers
Active research projects (see all research project in this area)
Characterizing the transcriptional regulation of the metastasis suppressor gene Growth Arrest Specific 1 (Gas1) in metastatic melanoma
Stéphane Gobeil
Stéphane Gobeil
UNDERSTANDING THE FUNCTION OF THE NEW METASTASIS SUPPRESSOR GENE GROWTH ARREST SPECIFIC 1 (GAS1)
Stéphane Gobeil
Stéphane Gobeil
Réseau de Médecine Génétique et Appliquée du Fonds de la recherche en santé du Québec (FRSQ) - Regroupement stratégique : « Next Generation Integrative Genomics (RS3) » du RMGA
Jacques Simard
Jacques Simard
CIHR Team in familial risks of breast cancer
Jacques Simard
Jacques Simard
Thème 3: Cancer de la prostate
Olivier Barbier, Alain Bélanger, Bernard Têtu
Olivier Barbier, Alain Bélanger, Bernard Têtu
Theme 1 : Glucuronidation et maladies cardiovasculaires
Olivier Barbier
Olivier Barbier
Theme 2 : Glucuronidation et maladies hépatiques
Olivier Barbier
Olivier Barbier
Pharmacogénomique et transplantation de cellules hématopoiëtiques (IRSC - Eric Lévesque, MD/Ph.D.)
Chantal Guillemette
Chantal Guillemette
Modulation de la voie de glucuronidation (IRSC)
Chantal Guillemette
Chantal Guillemette
Profil métabolique des estrogènes chez la femme (IRSC)
Chantal Guillemette
Chantal Guillemette
Recent publications (see all publications in this area)
Roy M, Richard JF, Dumas A, Vallieres L. CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis. Journal of neuroinflammation,
2012. Epub
Veilleux A, Cote JA, Blouin K, Nadeau M, Pelletier M, Marceau P, Laberge PY, Luu-The V, Tchernof A. Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 (AKR1C2) promotes adipogenesis in human preadipocytes. American journal of physiology. Endocrinology and metabolism,
2012. Epub
Laverdiere I, Caron P, Couture F, Levesque E, Guillemette C. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for monitoring drug exposure in hematopoietic stem cell transplant recipients. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
,
2012. Epub
Dube MC, Morisset AS, Tchernof A, Weisnagel SJ. Impact of a Mother's Weight History on Her Offspring. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC,
2012. 34: 34-8
Mavaddat N, Barrowdale D, Andrulis IL, Domchek SM, Eccles D, Nevanlinna H, Ramus SJ, Spurdle A, Robson M, Sherman M, Mulligan AM, Couch FJ, Engel C, McGuffog L, Healey S, Sinilnikova OM, Southey MC, Terry MB, Goldgar D, O'Malley F, John EM, Janavicius R, Tihomirova L, Hansen TV, Nielsen FC, Osorio A, Stavropoulou A, Benitez J, Manoukian S, Peissel B, Barile M, Volorio S, Pasini B, Dolcetti R, Putignano AL, Ottini L, Radice P, Hamann U, Rashid MU, Hogervorst FB, Kriege M, van der Luijt RB, for HEBON, Peock S, Frost D, Evans DG, Brewer C, Walker L, Rogers MT, Side LE, Houghton C, for EMBRACE, Weaver J, Godwin AK, Schmutzler RK, Wappenschmidt B, Meindl A, Kast K, Arnold N, Niederacher D, Sutter C, Deissler H, Gadzicki D, Preisler-Adams S, Varon-Mateeva R, Schonbuchner I, Gevensleben H, Stoppa-Lyonnet D, Belotti M, Barjhoux L, for GEMO Study Collaborators, Isaacs C, Peshkin BN, Caldes T, de la Hoya M, Canadas C, Heikkinen T, Heikkila P, Aittomaki K, Blanco I, Lazaro C, Brunet J, Agnarsson BA, Arason A, Barkardottir RB, Dumont M, Simard J, Montagna M, Agata S, D'Andrea E, Yan M, Fox S, for kConFab Investigators, Rebbeck TR, Rubinstein W, Tung N, Garber JE, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Szabo C, Offit K, Sakr R, Gaudet MM, Singer CF, Tea MK, Rappaport C, Mai PL, Greene MH, Sokolenko A, Imyanitov E, Toland AE, Senter L, Sweet K, Thomassen M, Gerdes AM, Kruse T, Caligo M, Aretini P, Rantala J, von Wachenfeld A, Henriksson K, for SWE-BRCA Collaborators, Steele L, Neuhausen SL, Nussbaum R, Beattie M, Odunsi K, Sucheston L, Gayther SA, Nathanson K, Gross J, Walsh C, Karlan B, Chenevix-Trench G, Easton DF, Antoniou AC, for the Consortium of Investigators of Modifiers of BRCA1/2. Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
2012. 21: 134-147
Lapointe J, Bouchard K, Patenaude AF, Maunsell E, Simard J, Dorval M. Incidence and predictors of positive and negative effects of BRCA1/2 genetic testing on familial relationships: a 3-year follow-up study. Genetics in medicine : official journal of the American College of Medical Genetics,
2012. 14: 60-8
Labrie, F. DHEA and cancer risk or prevention? In: Watson, Ronald Ross, ed. DHEA in human health and aging Boca Raton: CRC Press, 2012. p.153-172.
Laverdiere I, Caron P, Couture F, Guillemette C, Levesque E. Liquid Chromatography-Coupled Tandem Mass Spectrometry Based Assay to Evaluate Inosine-5'-monophosphate Dehydrogenase Activity in Peripheral Blood Mononuclear Cells from Stem Cell Transplant Recipients. Analytical chemistry,
2012. 84: 216-23
Choquette AC, Bouchard L, Drapeau V, Lemieux S, Tremblay A, Bouchard C, Vohl MC, Perusse L. Association between olfactory receptor genes, eating behavior traits and adiposity: results from the Quebec Family Study. Physiology & behavior,
2012. 105: 772-6
Bousquet M, St-Amour I, Vandal M, Julien P, Cicchetti F, Calon F. High-fat diet exacerbates MPTP-induced dopaminergic degeneration in mice. Neurobiology of disease,
2012. 45: 529-38
